In standard two-set blood culture collection, one culture is aerobic and the other is anaerobic.

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Blood cultures are designed with bottles that create different environments for bacterial growth. In a standard two-set collection, each set includes one aerobic bottle and one anaerobic bottle. This pair covers organisms with different oxygen needs: aerobes that require oxygen and anaerobes that grow best without it. Many bacteria are facultative anaerobes and can grow in either environment, so having both bottles increases the likelihood of recovery and overall yield. If only aerobic or only anaerobic bottles were used, some pathogens would be missed. So the statement is true.