Which statement is true about antifungal administration?

• A. They can be administered intravenously, orally, or topically.
• B. They are never given intravenously.
• C. They are always given orally.
• D. Topical administration is never used.

Answer: (A)

Antifungal therapy uses different routes depending on where the infection is and how the drug behaves in the body. Some infections require drugs to be in the bloodstream, so they’re given intravenously or orally because these routes allow systemic reach. Others are best treated locally on the skin or mucous membranes, so topical forms are used. For example, amphotericin B is given by IV for systemic infections, fluconazole can be given orally or IV with good bioavailability, and topical antifungals like terbinafine or clotrimazole are used for skin or nail infections. This variety means antifungals can be administered in multiple ways, making the statement that they can be given intravenously, orally, or topically true. The other options claim routes are never used or must be used in a single way, which isn’t accurate given the range of drugs and formulations available.